| Resumen |
Micropatterning and manipulation of mammalian and bacterial cells are important in
biomedical studies to perform in vitro assays and to evaluate biochemical processes accurately,
establishing the basis for implementing biomedical microelectromechanical systems (bioMEMS),
point-of-care (POC) devices, or organs-on-chips (OOC), which impact on neurological, oncological,
dermatologic, or tissue engineering issues as part of personalizedmedicine. Cell patterning represents
a crucial step in fundamental and applied biological studies in vitro, hence today there are a myriad of
materials and techniques that allow one to immobilize and manipulate cells, imitating the 3D in vivo
milieu. This review focuses on current physical cell patterning, plus chemical and a combination of
them both that utilizes different materials and cutting-edge micro-nanofabrication methodologies. |
